Closantel (R 31.520) in the treatment of "bernes" (Dermatobia hominis) (Lineu Jr. 1781)

Abstract

The therapeutical activity of closantel (R 31.520), a compound synthetized by Janssen Pharmaceutica, Beerse, Belgium, was observed in rats and bovines experimentally infested by "bernes" (Dermatobia hominis). Rats treated with a single dose (20 mg/kg I.M.) presented a percentage of cure of 88.9%, while in bovines a single dose of 10 and 12. 5 mg/kg showed a percentage of efficacy of 95.5 and 97.3% respectively. The preventive and larvicidal activities were also observed in rats and bovines infested by larvae of D. hominis.