Acute exposure to carbofuran insecticide evaluated by bioassay with flies Drosophyla melanogaster

Abstract

The acute exposure to carbofuran was studied using flies Drosophyla melanogaster after oral administration of this insecticide to female rats. The experimental group received carbofuran on single doses of 1, 4 or 7 mg/kg, and the control group received only the vehicle. All the animals were sacrified two hours after exposure, and their liver treated with the solvent acetone to extract the insecticide. The bioassay showed that carbofuran produced a median mortality of flies of 61.7%, 78.3% and 96.2% respectively after administration of the insecticide on doses of 1, 4 and 7 mg/kg.